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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3 [D835Y]' and Ligand = 'BDBM397427'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3 [D835Y]


(Homo sapiens (Human))		BDBM397427
PNG
(US9987278, Compound Reference 37)
Show SMILES CCCN(C)c1nc(NCCc2ccncc2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r|
Show InChI InChI=1S/C33H42N8O2/c1-7-21-40(5)31-28(24-36-33(38-31)35-20-17-26-15-18-34-19-16-26)14-13-27-10-8-11-29(23-27)37-32(43)25(2)41(6)30(42)12-9-22-39(3)4/h8-12,15-16,18-19,23-25H,7,17,20-22H2,1-6H3,(H,37,43)(H,35,36,38)/b12-9+/t25-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



BioCryst Pharmaceuticals



Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...

Bioorg Med Chem 17: 3934-58 (2009)


BindingDB Entry DOI: 10.7270/Q2J38VZJ
More data for this
Ligand-Target Pair