Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50105629 (CHEMBL54893 | N-(4-chloro-3-(3-methylbut-2-enyloxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 20.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcal£ Curated by ChEMBL | Assay Description Inhibitory activity against R172A mutant reverse transcriptase | J Med Chem 44: 1853-65 (2001) Article DOI: 10.1021/jm001095i BindingDB Entry DOI: 10.7270/Q20V8GJ7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50105629 (CHEMBL54893 | N-(4-chloro-3-(3-methylbut-2-enyloxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 23.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcal£ Curated by ChEMBL | Assay Description Inhibitory activity against wild-type HIV-1 reverse transcriptase | J Med Chem 44: 1853-65 (2001) Article DOI: 10.1021/jm001095i BindingDB Entry DOI: 10.7270/Q20V8GJ7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50105629 (CHEMBL54893 | N-(4-chloro-3-(3-methylbut-2-enyloxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcal£ Curated by ChEMBL | Assay Description Inhibitory activity against E138K mutant reverse transcriptase | J Med Chem 44: 1853-65 (2001) Article DOI: 10.1021/jm001095i BindingDB Entry DOI: 10.7270/Q20V8GJ7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50105629 (CHEMBL54893 | N-(4-chloro-3-(3-methylbut-2-enyloxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Effective concentration required against wild type HIV-1 reverse transcriptase | Bioorg Med Chem Lett 11: 2799-802 (2001) BindingDB Entry DOI: 10.7270/Q2J103P4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50105629 (CHEMBL54893 | N-(4-chloro-3-(3-methylbut-2-enyloxy...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB PubMed | n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 7 in the article) | Bioorg Med Chem Lett 11: 2799-802 (2001) BindingDB Entry DOI: 10.7270/Q2J103P4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |