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Found 1 hit Enz. Inhib. hit(s) with Target = 'Reverse transcriptase' and Ligand = 'BDBM50517394'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50517394
PNG
(CHEMBL4445956)
Show SMILES Cc1cc(cc(C)c1Oc1nc(NC2CCN(Cc3ccc(NS(C)(=O)=O)cc3)CC2)nc2CSCc12)C#N
Show InChI InChI=1S/C28H32N6O3S2/c1-18-12-21(14-29)13-19(2)26(18)37-27-24-16-38-17-25(24)31-28(32-27)30-22-8-10-34(11-9-22)15-20-4-6-23(7-5-20)33-39(3,35)36/h4-7,12-13,22,33H,8-11,15-17H2,1-3H3,(H,30,31,32)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant HIV1 reverse transcriptase using (DIG)-dUTP and biotin-labeled dNTPs as substrate after 1 hr by ELISA

J Med Chem 62: 1484-1501 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01656
BindingDB Entry DOI: 10.7270/Q29P351Z
More data for this
Ligand-Target Pair