Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM484772'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM484772 ((3R)-1′-[6-amino-5-(2,3-dichlorophenyl)pyraz...) Show SMILES N[C@H]1c2ccccc2CC11CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C23H23Cl2N5/c24-17-7-3-6-16(19(17)25)20-22(27)29-18(13-28-20)30-10-8-23(9-11-30)12-14-4-1-2-5-15(14)21(23)26/h1-7,13,21H,8-12,26H2,(H2,27,29)/t21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
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