Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM484785'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM484785 (US10934302, Example 34) Show SMILES NC1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCN([C@@H]2C[C@H](O)C2)c2cc(ccc12)C#N |r,wU:28.32,30.35,(-.94,12.54,;-2.08,11.51,;-3.59,11.83,;-4.36,13.16,;-5.9,13.16,;-6.67,11.83,;-5.9,10.49,;-4.36,10.49,;-3.33,9.35,;-1.92,9.98,;-1.92,8.44,;-.59,7.67,;.75,8.44,;.75,9.98,;-.59,10.75,;2.08,7.67,;2.08,6.13,;3.41,5.36,;4.75,6.13,;6.21,5.65,;7.12,6.9,;6.21,8.14,;4.75,7.67,;3.41,8.44,;6.69,4.19,;8.2,3.87,;8.67,2.4,;7.64,1.26,;8.12,-.21,;7.42,-1.58,;8.79,-2.28,;9.27,-3.74,;9.49,-.91,;6.13,1.58,;5.1,.43,;3.6,.75,;3.12,2.22,;4.15,3.36,;5.66,3.04,;2.57,-.39,;1.48,-1.48,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair