Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM484963'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM484963 (US10934302, Example 214) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(nc1CO)N1CCCCc2ccccc12 |r| Show InChI InChI=1S/C28H33N5O/c29-26-22-10-3-1-9-21(22)17-28(26)12-15-32(16-13-28)27-23(19-34)31-25(18-30-27)33-14-6-5-8-20-7-2-4-11-24(20)33/h1-4,7,9-11,18,26,34H,5-6,8,12-17,19,29H2/t26-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
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