Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM484966'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM484966 (US10934302, Example 217) Show SMILES N[C@@H]1c2ccc(F)cc2CC11CCN(CC1)c1ccc(Sc2ccnc(N)c2Cl)nc1 |r| Show InChI InChI=1S/C23H23ClFN5S/c24-20-18(5-8-28-22(20)27)31-19-4-2-16(13-29-19)30-9-6-23(7-10-30)12-14-11-15(25)1-3-17(14)21(23)26/h1-5,8,11,13,21H,6-7,9-10,12,26H2,(H2,27,28)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
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