Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM485022'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM485022 (US10934302, Example 273) Show SMILES N[C@@H]1c2ccccc2OC11CCN(CC1)c1cnc(SCC2CC2)cn1 |r| Show InChI InChI=1S/C20H24N4OS/c21-19-15-3-1-2-4-16(15)25-20(19)7-9-24(10-8-20)17-11-23-18(12-22-17)26-13-14-5-6-14/h1-4,11-12,14,19H,5-10,13,21H2/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair