Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM485038'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM485038 (US10934302, Example 289) Show SMILES Cc1cc(nn1-c1ccc(F)cc1F)C(=O)N1CCC2(Cc3ccccc3[C@H]2N)CC1 |r| Show InChI InChI=1S/C24H24F2N4O/c1-15-12-20(28-30(15)21-7-6-17(25)13-19(21)26)23(31)29-10-8-24(9-11-29)14-16-4-2-3-5-18(16)22(24)27/h2-7,12-13,22H,8-11,14,27H2,1H3/t22-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair