Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'SH2B adapter protein 2' and Ligand = 'BDBM485039'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SH2B adapter protein 2 (Human)	BDBM485039 (Syntheses of (S)-1-((S)-1-amino-1,3-dihydrospiro[i...) Show SMILES C[C@H](C(=O)N1CCC2(Cc3ccccc3[C@H]2N)CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H25FN2O/c1-15(16-6-8-18(23)9-7-16)21(26)25-12-10-22(11-13-25)14-17-4-2-3-5-19(17)20(22)24/h2-9,15,20H,10-14,24H2,1H3/t15-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Relay Therapeutics, Inc. US Patent					Assay Description SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...				US Patent US10934302 (2021) BindingDB Entry DOI: 10.7270/Q2ZW1Q1S
					More data for this Ligand-Target Pair