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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase 4' and Ligand = 'BDBM451728'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase 4


(Homo sapiens (Human))		BDBM451728
PNG
(6-(6-amino-5-(1-oxo-1,2,3,4- tetrahydroisoquinolin...)
Show SMILES Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc2NC(=O)COc2cc1F
Show InChI InChI=1S/C22H17FN4O3/c23-17-8-19-18(27-20(28)10-30-19)7-15(17)13-6-16(21(24)26-9-13)11-1-2-14-12(5-11)3-4-25-22(14)29/h1-2,5-9H,3-4,10H2,(H2,24,26)(H,25,29)(H,27,28)
PDB

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PC cid
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US Patent
n/an/a<40n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair