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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase 4' and Ligand = 'BDBM451758'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase 4


(Homo sapiens (Human))		BDBM451758
PNG
(4-(6-amino-5-(1- oxoisoindolin-5-yl)pyridin-3- yl)...)
Show SMILES CC(C)Oc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCc2c1)S(=O)(=O)N(C)C1CC1
Show InChI InChI=1S/C26H28N4O4S/c1-15(2)34-24-12-20(35(32,33)30(3)19-5-6-19)7-9-21(24)18-11-23(25(27)28-13-18)16-4-8-22-17(10-16)14-29-26(22)31/h4,7-13,15,19H,5-6,14H2,1-3H3,(H2,27,28)(H,29,31)
PDB

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PC cid
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US Patent
n/an/a<40n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE

US Patent


Assay Description
Biochemical IC50s were measured at Invitrogen using Z-lyte technology. Briefly, for STK4, the 2×STK4 (MST1)/Ser/Thr 07 mixture was prepared in 50 mM ...

US Patent US10710978 (2020)


BindingDB Entry DOI: 10.7270/Q2J67KZW
More data for this
Ligand-Target Pair