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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR' and Ligand = 'BDBM420515'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))		BDBM420515
PNG
(US10479784, Compound IA-28)
Show SMILES CC(C)(C)OC(=O)N1CCCN(CC1)C(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=N)OC(=N)c1ccccc1
Show InChI InChI=1S/C29H33N7O4/c1-29(2,3)40-28(38)36-15-7-14-35(16-17-36)27(37)21-12-10-19(11-13-21)22-18-33-24(30)23(34-22)26(32)39-25(31)20-8-5-4-6-9-20/h4-6,8-13,18,31-32H,7,14-17H2,1-3H3,(H2,30,33)
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<10n/an/an/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...

US Patent US10479784 (2019)


BindingDB Entry DOI: 10.7270/Q2GF0WVD
More data for this
Ligand-Target Pair