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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR' and Ligand = 'BDBM420521'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))		BDBM420521
PNG
(US10479784, Compound IA-34)
Show SMILES COC(=O)N1CCCN(CC1)C(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=N)OC(=N)c1ccccc1
Show InChI InChI=1S/C26H27N7O4/c1-36-26(35)33-13-5-12-32(14-15-33)25(34)19-10-8-17(9-11-19)20-16-30-22(27)21(31-20)24(29)37-23(28)18-6-3-2-4-7-18/h2-4,6-11,16,28-29H,5,12-15H2,1H3,(H2,27,30)
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<10n/an/an/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...

US Patent US10479784 (2019)


BindingDB Entry DOI: 10.7270/Q2GF0WVD
More data for this
Ligand-Target Pair