Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM25587'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM25587 (2,6-Disubstituted Pyrazine, 32 | 6-(1H-indol-4-ylo...) Show SMILES COc1cc(Nc2cncc(Oc3cccc4[nH]ccc34)n2)cc(OC)c1OC Show InChI InChI=1S/C21H20N4O4/c1-26-17-9-13(10-18(27-2)21(17)28-3)24-19-11-22-12-20(25-19)29-16-6-4-5-15-14(16)7-8-23-15/h4-12,23H,1-3H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	7.2	22
Cancer Research UK Centre for Cancer Therapeutics					Assay Description BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...				J Med Chem 51: 3261-74 (2008) Article DOI: 10.1021/jm070776b BindingDB Entry DOI: 10.7270/Q2X34VRR
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