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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf [V600E]' and Ligand = 'BDBM25594'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM25594
PNG
(2,6-Disubstituted Pyrazine, 57 | 5-({6-[(3,4,5-tri...)
Show SMILES COc1cc(Nc2cncc(Oc3cccc4C(=O)CCCc34)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H23N3O5/c1-28-19-10-14(11-20(29-2)23(19)30-3)25-21-12-24-13-22(26-21)31-18-9-5-6-15-16(18)7-4-8-17(15)27/h5-6,9-13H,4,7-8H2,1-3H3,(H,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair