Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ULK1' and Ligand = 'BDBM379376'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379376 (N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OC(F)(F)Oc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H11F5N4O2/c16-14(17,18)9-6-21-13(24-12(9)22-7-1-2-7)23-8-3-4-10-11(5-8)26-15(19,20)25-10/h3-7H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00873 BindingDB Entry DOI: 10.7270/Q2TX3K0J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379376 (N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OC(F)(F)Oc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H11F5N4O2/c16-14(17,18)9-6-21-13(24-12(9)22-7-1-2-7)23-8-3-4-10-11(5-8)26-15(19,20)25-10/h3-7H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...				Bioorg Med Chem 16: 4963-83 (2008) BindingDB Entry DOI: 10.7270/Q2N30084
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379376 (N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OC(F)(F)Oc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H11F5N4O2/c16-14(17,18)9-6-21-13(24-12(9)22-7-1-2-7)23-8-3-4-10-11(5-8)26-15(19,20)25-10/h3-7H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY US Patent					Assay Description ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...				US Patent US10774092 (2020) BindingDB Entry DOI: 10.7270/Q24F1TTD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM379376 (N4-cyclopropyl-N2-(2,2-difluorobenzo[d][1,3]dioxol...) Show SMILES FC(F)(F)c1cnc(Nc2ccc3OC(F)(F)Oc3c2)nc1NC1CC1 Show InChI InChI=1S/C15H11F5N4O2/c16-14(17,18)9-6-21-13(24-12(9)22-7-1-2-7)23-8-3-4-10-11(5-8)26-15(19,20)25-10/h3-7H,1-2H2,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00873 BindingDB Entry DOI: 10.7270/Q2TX3K0J
					More data for this Ligand-Target Pair