Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM50469471'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50469471 (CHEMBL4277562) Show SMILES [H][C@]12CN(c3nc(nc(n3)-c3cnc(N)cc3C(F)F)N3C[C@]4([H])C[C@@]3([H])CO4)[C@]([H])(CO1)C2 |r| Show InChI InChI=1S/C19H21F2N7O2/c20-16(21)13-3-15(22)23-4-14(13)17-24-18(27-5-11-1-9(27)7-29-11)26-19(25-17)28-6-12-2-10(28)8-30-12/h3-4,9-12,16H,1-2,5-8H2,(H2,22,23)/t9-,10-,11-,12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Binding affinity to recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus after 1 hr by TR-FRET displac...				J Med Chem 61: 10084-10105 (2018) Article DOI: 10.1021/acs.jmedchem.8b01262 BindingDB Entry DOI: 10.7270/Q2X92F07
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