Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1/pim-2/pim-3' and Ligand = 'BDBM192582'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM192582 (US9187486, 48) Show SMILES N[C@H]1C[C@@H](F)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H20F3N7/c23-13-8-14(26)12-31(11-13)20-6-7-27-10-19(20)29-22-28-9-15-4-5-18(30-32(15)22)21-16(24)2-1-3-17(21)25/h1-7,9-10,13-14H,8,11-12,26H2,(H,28,29)/t13-,14+/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	983	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
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