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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1/pim-2/pim-3' and Ligand = 'BDBM238728'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1/pim-2/pim-3


(Homo sapiens (Human))		BDBM238728
PNG
(US9394297, 409)
Show SMILES Cc1nc2cccc(-c3cc4C(=O)NC5(CCOCC5)c4[nH]3)c2nc1NC(C)(C)C
Show InChI InChI=1S/C23H27N5O2/c1-13-20(27-22(2,3)4)26-18-14(6-5-7-16(18)24-13)17-12-15-19(25-17)23(28-21(15)29)8-10-30-11-9-23/h5-7,12,25H,8-11H2,1-4H3,(H,26,27)(H,28,29)
PDB

UniProtKB/SwissProt

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GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.76E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...

J Med Chem 59: 6407-30 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G
More data for this
Ligand-Target Pair