Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1/pim-2/pim-3' and Ligand = 'BDBM50536099'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM50536099 (CHEMBL4546373) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1N=C(NC(C)(C)C)N(C)S2(=O)=O |r,t:19| Show InChI InChI=1S/C19H23N5O3S/c1-10-15-12(17(25)20-10)9-13(21-15)11-7-6-8-14-16(11)22-18(23-19(2,3)4)24(5)28(14,26)27/h6-10,21H,1-5H3,(H,20,25)(H,22,23)/t10-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610 BindingDB Entry DOI: 10.7270/Q2125X4G
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