BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-3' and Ligand = 'BDBM50061604'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061604
PNG
(CHEMBL3394169 | US9321756, 173)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C21H21N5OS/c22-21-26-25-20(28-21)13-9-10-17-15(11-13)16(12-23-17)18-7-4-8-19(24-18)27-14-5-2-1-3-6-14/h4,7-12,14,23H,1-3,5-6H2,(H2,22,26)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 17.8n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50061604
PNG
(CHEMBL3394169 | US9321756, 173)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCCC4)n3)c2c1
Show InChI InChI=1S/C21H21N5OS/c22-21-26-25-20(28-21)13-9-10-17-15(11-13)16(12-23-17)18-7-4-8-19(24-18)27-14-5-2-1-3-6-14/h4,7-12,14,23H,1-3,5-6H2,(H2,22,26)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...

Bioorg Med Chem Lett 25: 775-80 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.091
BindingDB Entry DOI: 10.7270/Q2WQ05G8
More data for this
Ligand-Target Pair