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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50459008'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine-protein kinase ATM


(Homo sapiens (Human))		BDBM50459008
PNG
(CHEMBL4217379)
Show SMILES C[C@H](Nc1c(nnc2ccc(cc12)-c1ccc(NCCN(C)C)nc1)C(N)=O)C1CCOCC1 |r|
Show InChI InChI=1S/C25H33N7O2/c1-16(17-8-12-34-13-9-17)29-23-20-14-18(4-6-21(20)30-31-24(23)25(26)33)19-5-7-22(28-15-19)27-10-11-32(2)3/h4-7,14-17H,8-13H2,1-3H3,(H2,26,33)(H,27,28)(H,29,30)/t16-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 61n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM autophosphorylation at Ser1981 residue in human HT-29 cells measured after 1 hr by Hoechst staining based fluorescence assay

ACS Med Chem Lett 9: 809-814 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00200
BindingDB Entry DOI: 10.7270/Q27D2XRQ
More data for this
Ligand-Target Pair