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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50459013'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine-protein kinase ATM


(Homo sapiens (Human))		BDBM50459013
PNG
(CHEMBL4205554)
Show SMILES CNC(=O)c1nnc2ccc(cc2c1N[C@@H](C)C1CCOCC1)-c1ccc(COC)nc1 |r|
Show InChI InChI=1S/C24H29N5O3/c1-15(16-8-10-32-11-9-16)27-22-20-12-17(18-4-6-19(14-31-3)26-13-18)5-7-21(20)28-29-23(22)24(30)25-2/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,25,30)(H,27,28)/t15-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM autophosphorylation at Ser1981 residue in human HT-29 cells measured after 1 hr by Hoechst staining based fluorescence assay

ACS Med Chem Lett 9: 809-814 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00200
BindingDB Entry DOI: 10.7270/Q27D2XRQ
More data for this
Ligand-Target Pair