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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50535979'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine-protein kinase ATM


(Homo sapiens (Human))		BDBM50535979
PNG
(CHEMBL4533539)
Show SMILES COCc1ccc(cn1)-c1cc2c(N[C@@H](C)C3CCOCC3)c(cnc2cc1F)C(N)=O |r|
Show InChI InChI=1S/C24H27FN4O3/c1-14(15-5-7-32-8-6-15)29-23-19-9-18(16-3-4-17(13-31-2)27-11-16)21(25)10-22(19)28-12-20(23)24(26)30/h3-4,9-12,14-15H,5-8,13H2,1-2H3,(H2,26,30)(H,28,29)/t14-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...

J Med Chem 59: 6281-92 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00519
BindingDB Entry DOI: 10.7270/Q2NV9NR8
More data for this
Ligand-Target Pair