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Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM50535996'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine-protein kinase ATM


(Homo sapiens (Human))		BDBM50535996
PNG
(CHEMBL4549865)
Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1cnn(C)c1)C(N)=O
Show InChI InChI=1S/C20H25N5O/c1-4-13(5-2)9-23-19-16-8-14(15-10-24-25(3)12-15)6-7-18(16)22-11-17(19)20(21)26/h6-8,10-13H,4-5,9H2,1-3H3,(H2,21,26)(H,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 525n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...

J Med Chem 59: 6281-92 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00519
BindingDB Entry DOI: 10.7270/Q2NV9NR8
More data for this
Ligand-Target Pair