BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with Target = 'Sigma non-opioid intracellular receptor 1' and Ligand = 'BDBM50019742'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	302	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description The compound was tested for binding affinity of Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG ligand				J Med Chem 42: 4446-55 (1999) BindingDB Entry DOI: 10.7270/Q2NS0VMV
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against the sigma receptor from guinea pig brain using the radioligand [3H]SKF-10047				Bioorg Med Chem Lett 2: 165-170 (1992) Article DOI: 10.1016/S0960-894X(01)80443-1 BindingDB Entry DOI: 10.7270/Q28P610P
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	820	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligand				J Med Chem 37: 364-70 (1994) BindingDB Entry DOI: 10.7270/Q2WD416F
DuPont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Mus musculus (Mouse))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	820	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Du Pont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description In vitro binding affinity for the mouse sigma opioid receptor				J Med Chem 35: 4344-61 (1992) BindingDB Entry DOI: 10.7270/Q28P614G
Du Pont Merck Pharmaceutical Company Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	893	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane				Bioorg Med Chem Lett 18: 5238-41 (2008) Article DOI: 10.1016/j.bmcl.2008.08.065 BindingDB Entry DOI: 10.7270/Q2DB82SZ
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	908	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDA-IRP Curated by ChEMBL					Assay Description Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand				J Med Chem 46: 2589-98 (2003) Article DOI: 10.1021/jm030008u BindingDB Entry DOI: 10.7270/Q2H70GJN
NIDA-IRP Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	908	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pavia Curated by ChEMBL					Assay Description Displacement of [3H]-pentazocine from sigma 1 receptor in guinea pig brain cortical membrane after 120 mins by scintillation counting analysis				Eur J Med Chem 124: 649-665 (2016) Article DOI: 10.1016/j.ejmech.2016.08.067 BindingDB Entry DOI: 10.7270/Q2MS3VSX
University of Pavia Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor type 2 in whole rat brain homogenates except cerebellum using radioligand ([3H]DTG) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranes				J Med Chem 35: 4683-9 (1993) BindingDB Entry DOI: 10.7270/Q20865XT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine				J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranes				J Med Chem 35: 4683-9 (1993) BindingDB Entry DOI: 10.7270/Q20865XT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
University of Missouri-Columbia Curated by ChEMBL					Assay Description Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membrane				Bioorg Med Chem 16: 755-61 (2008) Article DOI: 10.1016/j.bmc.2007.10.037 BindingDB Entry DOI: 10.7270/Q2251K1T
University of Missouri-Columbia Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Missouri-Columbia Curated by ChEMBL					Assay Description Displacement of [3H]pentazocine from sigma1 receptor in guinea pig membrane in presence of phenytoin				Bioorg Med Chem 16: 755-61 (2008) Article DOI: 10.1016/j.bmc.2007.10.037 BindingDB Entry DOI: 10.7270/Q2251K1T
University of Missouri-Columbia Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Inhibition of specific binding of [3H]DTG to sigma receptor in Guinea pig brain membranes				J Med Chem 35: 4683-9 (1993) BindingDB Entry DOI: 10.7270/Q20865XT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Binding affinity was evaluated using [3H]pentazocine binding to sigma-1 receptor from guinea pig brain				J Med Chem 40: 4340-46 (1998) Article DOI: 10.1021/jm9705519 BindingDB Entry DOI: 10.7270/Q26H4J34
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50019742 (9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Otsuka Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes				J Med Chem 43: 177-89 (2000) BindingDB Entry DOI: 10.7270/Q2P84CK8
Otsuka Pharmaceutical Company Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair