BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 1' and Ligand = 'BDBM176446'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176446 (US9688710, 45 N-(2-methyl-1-(4-methylpiperazin-1-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...				J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7
Lexicon Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM176446 (US9688710, 45 N-(2-methyl-1-(4-methylpiperazin-1-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.3	n/a
Lexicon Pharmaceuticals, Inc. US Patent					Assay Description Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...				US Patent US9688710 (2017) BindingDB Entry DOI: 10.7270/Q2154F7P
Lexicon Pharmaceuticals, Inc. US Patent					More data for this Ligand-Target Pair