BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50265180'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265180
PNG
(5-((4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydro...)
Show SMILES CN(Cc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)C(=O)c1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |r,wU:17.18,22.23,15.15,wD:24.26,20.21,(17.01,-50.45,;17.03,-48.91,;15.7,-48.12,;14.36,-48.88,;14.34,-50.41,;13.01,-51.16,;11.7,-50.38,;10.37,-51.14,;9.02,-50.37,;7.68,-51.13,;6.35,-50.36,;6.35,-48.83,;7.69,-48.05,;9.03,-48.83,;10.36,-48.06,;5.01,-51.13,;3.68,-50.35,;2.35,-51.13,;1.01,-50.36,;-.32,-51.14,;2.35,-52.67,;1.02,-53.45,;3.68,-53.44,;3.68,-54.98,;5.01,-52.67,;6.35,-53.45,;11.71,-48.86,;13.03,-48.11,;18.37,-48.15,;18.38,-46.6,;19.7,-48.93,;19.68,-50.46,;21.01,-51.25,;22.35,-50.49,;22.36,-48.94,;21.03,-48.16,;23.11,-47.6,;22.33,-46.27,;24.65,-47.58,;23.67,-51.26,;23.67,-52.8,;22.33,-53.55,;22.32,-55.08,;23.64,-55.86,;23.63,-57.4,;24.97,-55.11,;24.98,-53.59,;26.33,-52.83,;26.34,-51.29,;27.68,-50.53,;27.69,-48.99,;29.04,-48.23,;26.36,-48.2,;25.02,-48.96,;25.01,-50.5,)|
Show InChI InChI=1S/C42H36ClNO11/c1-44(19-22-4-2-21(3-5-22)14-25-15-23(7-13-32(25)43)40-39(50)38(49)37(48)35(20-45)55-40)41(51)24-6-10-28(31(16-24)42(52)53)36-29-11-8-26(46)17-33(29)54-34-18-27(47)9-12-30(34)36/h2-13,15-18,35,37-40,45-46,48-50H,14,19-20H2,1H3,(H,52,53)/t35-,37-,38+,39-,40+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair