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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50265229'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265229
PNG
(3-(3-((4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-tr...)
Show SMILES CC(C)CN(CCCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)C(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F |r,c:45,47,t:42|
Show InChI InChI=1S/C41H51BClF2N3O7/c1-25(2)23-46(37(50)16-12-31-10-11-32-22-35-26(3)19-27(4)47(35)42(44,45)48(31)32)17-5-6-18-54-33-13-7-28(8-14-33)20-30-21-29(9-15-34(30)43)41-40(53)39(52)38(51)36(24-49)55-41/h7-11,13-15,19,21-22,25,36,38-41,49,51-53H,5-6,12,16-18,20,23-24H2,1-4H3/t36-,38-,39+,40-,41+/m1/s1
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Similars
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair