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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50381551'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50381551
PNG
(CHEMBL2018093)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2cc3ccccc3s2)ccc1Cl |r|
Show InChI InChI=1S/C21H21ClO5S/c22-15-6-5-11(7-13-9-12-3-1-2-4-17(12)28-13)8-14(15)21-20(26)19(25)18(24)16(10-23)27-21/h1-6,8-9,16,18-21,23-26H,7,10H2/t16-,18-,19+,20-,21+/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation counting

Bioorg Med Chem 20: 3263-79 (2012)


Article DOI: 10.1016/j.bmc.2012.03.051
BindingDB Entry DOI: 10.7270/Q2W66MSS
More data for this
Ligand-Target Pair