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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50467849'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50467849
PNG
(CHEMBL4280615)
Show SMILES CC(C)Oc1ccc(Cc2cc([C@@H]3S[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)cc2C)cc1 |r|
Show InChI InChI=1S/C23H30O6S/c1-12(2)29-16-6-4-14(5-7-16)9-15-10-17(18(25)8-13(15)3)23-22(28)21(27)20(26)19(11-24)30-23/h4-8,10,12,19-28H,9,11H2,1-3H3/t19-,20-,21+,22-,23+/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
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Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in Na-dependent [14C]-methyl-alpha-D-glucopyranoside uptake after 1 hr by mi...

Bioorg Med Chem Lett 28: 3534-3539 (2018)


Article DOI: 10.1016/j.bmcl.2018.09.035
BindingDB Entry DOI: 10.7270/Q2V40XWK
More data for this
Ligand-Target Pair