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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/potassium-transporting ATPase subunit alpha-2/beta-1' and Ligand = 'BDBM444983'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/potassium-transporting ATPase subunit alpha-2/beta-1


(Homo sapiens (Human))		BDBM444983
PNG
(US10668094, Compound DBz-(cyclic))
Show SMILES C[C@@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]1C[C@H](O)[C@H](OC2CCN(Cc3ccccc3)CC(C)O2)[C@H](C)O1)O[C@H]1CC[C@@]2(C)C(CCC3C2C[C@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1 |r,t:61|
Show InChI InChI=1S/C48H71NO12/c1-27-24-49(25-30-9-7-6-8-10-30)18-15-41(56-27)60-44-28(2)58-43(23-38(44)51)61-45-29(3)57-42(22-37(45)50)59-33-13-16-46(4)32(20-33)11-12-35-36(46)21-39(52)47(5)34(14-17-48(35,47)54)31-19-40(53)55-26-31/h6-10,19,27-29,32-39,41-45,50-52,54H,11-18,20-26H2,1-5H3/t27?,28-,29-,32?,33-,34+,35?,36?,37-,38-,39-,41?,42-,43-,44+,45+,46-,47-,48-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
 10.1n/an/an/an/an/an/an/an/a



Yeda Research and Development Co. Ltd.

US Patent


Assay Description
To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...

US Patent US10668094 (2020)


BindingDB Entry DOI: 10.7270/Q2FX7DH9
More data for this
Ligand-Target Pair