Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50051073![]() (CHEMBL3318132) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells at holding potential of -120 mV by manual electrophysiology method | Bioorg Med Chem Lett 28: 3141-3149 (2018) Article DOI: 10.1016/j.bmcl.2018.08.007 BindingDB Entry DOI: 10.7270/Q2VD724S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50051073![]() (CHEMBL3318132) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Peptides International, Inc. Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in xenopus oocytes at -80 mV holding potential by two-electrode voltage-clamp method | Bioorg Med Chem 26: 2738-2758 (2018) Article DOI: 10.1016/j.bmc.2017.09.029 BindingDB Entry DOI: 10.7270/Q2Q52S8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50051073![]() (CHEMBL3318132) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysis | J Med Chem 57: 6623-31 (2014) Article DOI: 10.1021/jm500687u BindingDB Entry DOI: 10.7270/Q22B90P2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50051073![]() (CHEMBL3318132) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of human NaV1.7 at -140 mV holding potential by whole-cell patch clamp assay | J Med Chem 58: 2299-314 (2015) Article DOI: 10.1021/jm501765v BindingDB Entry DOI: 10.7270/Q2F47QVK | |||||||||||
More data for this Ligand-Target Pair |