Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compound | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Budapest University of Technology and Economics Curated by ChEMBL | Assay Description H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determined | J Med Chem 47: 5620-9 (2004) Article DOI: 10.1021/jm040809c BindingDB Entry DOI: 10.7270/Q2TX3G43 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem 21: 4938-50 (2013) Article DOI: 10.1016/j.bmc.2013.06.063 BindingDB Entry DOI: 10.7270/Q2NZ891C | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Inhibitory activity against human GABA transporter-1 (hGAT1) | J Med Chem 37: 2334-42 (1994) BindingDB Entry DOI: 10.7270/Q2P849XX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-University M£nchen Curated by ChEMBL | Assay Description Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysis | Bioorg Med Chem 27: 1232-1245 (2019) Article DOI: 10.1016/j.bmc.2019.02.015 BindingDB Entry DOI: 10.7270/Q2P272J5 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-University Munich Curated by ChEMBL | Assay Description Inhibition of mouse GAT1 assessed as reduction in GABA uptake | J Med Chem 61: 6211-6235 (2018) Article DOI: 10.1021/acs.jmedchem.8b00629 BindingDB Entry DOI: 10.7270/Q2MW2KPX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University Curated by ChEMBL | Assay Description Inhibition of GAT1 transport activity | Bioorg Med Chem Lett 16: 225-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.004 BindingDB Entry DOI: 10.7270/Q29887SD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Mus musculus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.56E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhengzhou University Curated by ChEMBL | Assay Description Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cells | Bioorg Med Chem Lett 17: 3769-73 (2007) Article DOI: 10.1016/j.bmcl.2007.04.010 BindingDB Entry DOI: 10.7270/Q2W66MMJ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Mus musculus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.07E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysis | J Med Chem 56: 2160-4 (2013) Article DOI: 10.1021/jm301872x BindingDB Entry DOI: 10.7270/Q2G73G26 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Mus musculus) | BDBM50020883![]() ((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.07E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysis | J Med Chem 56: 2160-4 (2013) Article DOI: 10.1021/jm301872x BindingDB Entry DOI: 10.7270/Q2G73G26 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |