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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium- and chloride-dependent GABA transporter 1' and Ligand = 'BDBM50491703'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50491703
PNG
(CHEMBL2387657)
Show SMILES OC(=O)C1CCCN(CCO\C=C/c2ccc(F)cc2C(=O)c2cccc(F)c2)C1
Show InChI InChI=1S/C23H23F2NO4/c24-19-5-1-3-17(13-19)22(27)21-14-20(25)7-6-16(21)8-11-30-12-10-26-9-2-4-18(15-26)23(28)29/h1,3,5-8,11,13-14,18H,2,4,9-10,12,15H2,(H,28,29)/b11-8-
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Article
PubMed
n/an/a 794n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis

Bioorg Med Chem 21: 3363-78 (2013)


Article DOI: 10.1016/j.bmc.2013.02.056
BindingDB Entry DOI: 10.7270/Q23N269C
More data for this
Ligand-Target Pair