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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium- and chloride-dependent GABA transporter 1' and Ligand = 'BDBM50491719'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50491719
PNG
(CHEMBL2387660)
Show SMILES OC(=O)C1CCCN(CCO\C=C\c2cc(F)ccc2C(=O)c2ccc(F)cc2)C1
Show InChI InChI=1S/C23H23F2NO4/c24-19-5-3-16(4-6-19)22(27)21-8-7-20(25)14-17(21)9-12-30-13-11-26-10-1-2-18(15-26)23(28)29/h3-9,12,14,18H,1-2,10-11,13,15H2,(H,28,29)/b12-9+
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PC cid
PC sid
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Article
PubMed
n/an/a 2.09E+4n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis

Bioorg Med Chem 21: 3363-78 (2013)


Article DOI: 10.1016/j.bmc.2013.02.056
BindingDB Entry DOI: 10.7270/Q23N269C
More data for this
Ligand-Target Pair