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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium- and chloride-dependent GABA transporter 1' and Ligand = 'BDBM50491727'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 1


(Rattus norvegicus)		BDBM50491727
PNG
(CHEMBL2387670)
Show SMILES OC(=O)C1CCCN(CCO\C=C\c2ccc(F)cc2Cc2ccccc2F)C1
Show InChI InChI=1S/C23H25F2NO3/c24-21-8-7-17(20(15-21)14-18-4-1-2-6-22(18)25)9-12-29-13-11-26-10-3-5-19(16-26)23(27)28/h1-2,4,6-9,12,15,19H,3,5,10-11,13-14,16H2,(H,27,28)/b12-9+
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.69E+3n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysis

Bioorg Med Chem 21: 3363-78 (2013)


Article DOI: 10.1016/j.bmc.2013.02.056
BindingDB Entry DOI: 10.7270/Q23N269C
More data for this
Ligand-Target Pair