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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium-dependent noradrenaline transporter' and Ligand = 'BDBM388484'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM388484
PNG
(US9944618, Compound ID No. 18)
Show SMILES CNC[C@@H]([C@H](OCc1cc(C)on1)c1ccccc1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C25H26N2O2/c1-18-14-23(27-29-18)17-28-25(20-9-4-3-5-10-20)24(16-26-2)22-13-12-19-8-6-7-11-21(19)15-22/h3-15,24-26H,16-17H2,1-2H3/t24-,25-/m1/s1
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US Patent
 1.80n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute



Assay Description
NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...

Bioorg Med Chem Lett 19: 1164-7 (2009)


BindingDB Entry DOI: 10.7270/Q26D5WBR
More data for this
Ligand-Target Pair