Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293T cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and mea... | J Med Chem 63: 3834-3867 (2020) Article DOI: 10.1021/acs.jmedchem.9b01237 BindingDB Entry DOI: 10.7270/Q26113PD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
West China Hospital of Sichuan University Curated by ChEMBL | Assay Description Inhibition of URAT1 (unknown origin) | Eur J Med Chem 166: 186-196 (2019) Article DOI: 10.1016/j.ejmech.2019.01.043 BindingDB Entry DOI: 10.7270/Q20C50BS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02057 BindingDB Entry DOI: 10.7270/Q2N3020C | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The IC50 value of URAT1 inhibition for the crystalline form A of TY706 of the present invention was determined according to the following method:Afte... | Citation and Details BindingDB Entry DOI: 10.7270/Q29P34TV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tianjin Medical University Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293 cells assessed as reduction in [8-14C]uric acid uptake | Bioorg Med Chem Lett 29: 383-388 (2019) Article DOI: 10.1016/j.bmcl.2018.12.036 BindingDB Entry DOI: 10.7270/Q2MP56PF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac... | ACS Med Chem Lett 8: 299-303 (2017) Article DOI: 10.1021/acsmedchemlett.6b00465 BindingDB Entry DOI: 10.7270/Q2QF8W46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac... | ACS Med Chem Lett 8: 299-303 (2017) Article DOI: 10.1021/acsmedchemlett.6b00465 BindingDB Entry DOI: 10.7270/Q2QF8W46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tianjin Medical University Curated by ChEMBL | Assay Description Inhibition of human URAT1 | Bioorg Med Chem Lett 29: 383-388 (2019) Article DOI: 10.1016/j.bmcl.2018.12.036 BindingDB Entry DOI: 10.7270/Q2MP56PF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00223 BindingDB Entry DOI: 10.7270/Q2CC148F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Curated by ChEMBL | Assay Description Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac... | ACS Med Chem Lett 8: 299-303 (2017) Article DOI: 10.1021/acsmedchemlett.6b00465 BindingDB Entry DOI: 10.7270/Q2QF8W46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US10093631 (2018) BindingDB Entry DOI: 10.7270/Q2K64M4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US11020397 (2021) BindingDB Entry DOI: 10.7270/Q2JQ1453 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US11020397 (2021) BindingDB Entry DOI: 10.7270/Q2JQ1453 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US10752613 (2020) BindingDB Entry DOI: 10.7270/Q2KP856K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use... | US Patent US10093658 (2018) BindingDB Entry DOI: 10.7270/Q2NZ89PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Acquist LLC US Patent | Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:... | US Patent US10093658 (2018) BindingDB Entry DOI: 10.7270/Q2NZ89PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM37953![]() (US10093631, Compound Lesinurad | US10336710, Lesin...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2154FFC | |||||||||||
More data for this Ligand-Target Pair |