Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sonic hedgehog protein (Mus musculus (Mouse)) | BDBM50249522![]() (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assay | J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sonic hedgehog protein (Mus musculus (Mouse)) | BDBM50249522![]() (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Simcere Pharmaceutical Co. Ltd Curated by ChEMBL | Assay Description Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay | Bioorg Med Chem Lett 23: 6777-83 (2013) Article DOI: 10.1016/j.bmcl.2013.10.022 BindingDB Entry DOI: 10.7270/Q2R49S7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sonic hedgehog protein (Mus musculus (Mouse)) | BDBM50249522![]() (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assay | Bioorg Med Chem Lett 19: 5576-81 (2009) Article DOI: 10.1016/j.bmcl.2009.08.049 BindingDB Entry DOI: 10.7270/Q21R6QMJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sonic hedgehog protein (Homo sapiens (Human)) | BDBM50249522![]() (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sonic hedgehog protein (Homo sapiens (Human)) | BDBM50249522![]() (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc. Curated by ChEMBL | Assay Description Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay i... | J Med Chem 54: 2592-601 (2011) Article DOI: 10.1021/jm1008924 BindingDB Entry DOI: 10.7270/Q2NS0V6G | |||||||||||
More data for this Ligand-Target Pair |