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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein' and Ligand = 'BDBM50302110'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))		BDBM50302110
PNG
(CHEMBL583032 | N-(4-chloro-3-(1H-indol-2-yl)phenyl...)
Show SMILES Cc1nc(ccc1C(=O)Nc1ccc(Cl)c(c1)-c1cc2ccccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C22H15ClF3N3O/c1-12-15(7-9-20(27-12)22(24,25)26)21(30)28-14-6-8-17(23)16(11-14)19-10-13-4-2-3-5-18(13)29-19/h2-11,29H,1H3,(H,28,30)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assay

Bioorg Med Chem Lett 19: 5576-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.049
BindingDB Entry DOI: 10.7270/Q21R6QMJ
More data for this
Ligand-Target Pair