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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein' and Ligand = 'BDBM50302118'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))		BDBM50302118
PNG
(CHEMBL571352 | N-(4-chloro-3-(phenylcarbamoyl)phen...)
Show SMILES Cc1nc(ccc1C(=O)Nc1ccc(Cl)c(c1)C(=O)Nc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H15ClF3N3O2/c1-12-15(8-10-18(26-12)21(23,24)25)19(29)28-14-7-9-17(22)16(11-14)20(30)27-13-5-3-2-4-6-13/h2-11H,1H3,(H,27,30)(H,28,29)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assay

Bioorg Med Chem Lett 19: 5576-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.049
BindingDB Entry DOI: 10.7270/Q21R6QMJ
More data for this
Ligand-Target Pair