Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingosine kinase 2 (Homo sapiens (Human)) | BDBM50139649 (CHEMBL3764617) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus) Curated by ChEMBL | Assay Description Inhibition of human SK2 using D-erythro sphingosine as substrate and gamma[33P]ATP by Lineweaver-Burk plot analysis | J Med Chem 59: 965-84 (2016) Article DOI: 10.1021/acs.jmedchem.5b01439 BindingDB Entry DOI: 10.7270/Q2WW7KJH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine kinase 2 (Homo sapiens (Human)) | BDBM50139649 (CHEMBL3764617) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine kinase 2 (Homo sapiens (Human)) | BDBM50139649 (CHEMBL3764617) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human SphK2 assessed as decrease in [33P]SIP production using sphingosine as substrate in presence of [gamma33P]-ATP by sci... | Citation and Details Article DOI: 10.1016/j.bmc.2020.115941 BindingDB Entry DOI: 10.7270/Q23B63ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine kinase 2 (Homo sapiens (Human)) | BDBM50139649 (CHEMBL3764617) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Tech Curated by ChEMBL | Assay Description Inhibition of recombinant human His6/HA-fusion-tagged SphK2 expressed in baculovirus infected sf9 insect cells using d-erythro-sphingosine as substra... | J Med Chem 63: 1178-1198 (2020) Article DOI: 10.1021/acs.jmedchem.9b01508 BindingDB Entry DOI: 10.7270/Q2WH2T9K | |||||||||||
More data for this Ligand-Target Pair |