BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Steroid 17-alpha-hydroxylase/17,20 lyase' and Ligand = 'BDBM50063477'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50063477 ((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)				J Med Chem 41: 902-12 (1998) Article DOI: 10.1021/jm970568r BindingDB Entry DOI: 10.7270/Q2GH9H2N
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50063477 ((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Inhibition of human testicular microsomal Cytochrome P450 17A1				J Med Chem 41: 902-12 (1998) Article DOI: 10.1021/jm970568r BindingDB Entry DOI: 10.7270/Q2GH9H2N
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Rattus norvegicus (Rat))	BDBM50063477 ((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Inhibition of rat Cytochrome P450 17A1				J Med Chem 41: 902-12 (1998) Article DOI: 10.1021/jm970568r BindingDB Entry DOI: 10.7270/Q2GH9H2N
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50063477 ((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description In vitro inhibitory concentration against Cytochrome P450 17 expressed in Escherichia coli				J Med Chem 48: 2972-84 (2005) Article DOI: 10.1021/jm040202w BindingDB Entry DOI: 10.7270/Q2TH8NHV
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 17-alpha-hydroxylase/17,20 lyase (Homo sapiens (Human))	BDBM50063477 ((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Accelrys Curated by ChEMBL					Assay Description In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...				J Med Chem 46: 2345-51 (2003) Article DOI: 10.1021/jm020576u BindingDB Entry DOI: 10.7270/Q2WD41B7
Accelrys Curated by ChEMBL					More data for this Ligand-Target Pair