Compile Data Set for Download or QSAR

Found 18 hits Enz. Inhib. hit(s) with Target = 'Stimulator of interferon genes protein' and Ligand = 'BDBM50584863'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stimulator of interferon genes protein (Mus musculus)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in mouse RAW-Lucia ISG-KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1-Dual KO-STING cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP report...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human STING G230A/R293Q double mutant cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) assessed as induction of protein dimerization incubated...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/WT genotype in human PBMC cells assessed as increase in iFIT3 mRNA expression incubated for 6 hrs by RT-PCR ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/HAQ genotype in human PBMC cells assessed as increase in iFIT3 mRNA expression incubated for 6 hrs by RT-PCR...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/R232H genotype in human PBMC cells assessed as increase in iFIT3 mRNA expression incubated for 6 hrs by RT-P...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/WT genotype in human PBMC cells assessed as increase in MX1 mRNA expression incubated for 6 hrs by RT-PCR an...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/HAQ genotype in human PBMC cells assessed as increase in MX1 mRNA expression incubated for 6 hrs by RT-PCR a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1 Dual KO-STING cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gen...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of STING pathway harboring WT/R232H genotype in human PBMC cells assessed as increase in MX1 mRNA expression incubated for 6 hrs by RT-PCR...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Human)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (Mus musculus)	BDBM50584863 (CHEMBL5077683) Show SMILES Cc1cc(C(O)=O)c2oc(CNC(=O)c3cnn4cccnc34)c(Cl)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene ass...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01986 BindingDB Entry DOI: 10.7270/Q29S1VZM
					More data for this Ligand-Target Pair