Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM407025 ((3S,4S)-4-amino-1-({4-[(3-fluoropyridin-4-yl)amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assay | Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM407025 ((3S,4S)-4-amino-1-({4-[(3-fluoropyridin-4-yl)amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. US Patent | Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec... | US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R | |||||||||||
More data for this Ligand-Target Pair |