Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TRAF2 and NCK-interacting protein kinase (Homo sapiens (Human)) | BDBM50535489![]() (CHEMBL4471729) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated... | Bioorg Med Chem Lett 29: 1962-1967 (2019) Article DOI: 10.1016/j.bmcl.2019.05.032 BindingDB Entry DOI: 10.7270/Q2PZ5DBT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
TRAF2 and NCK-interacting protein kinase (Homo sapiens (Human)) | BDBM50535489![]() (CHEMBL4471729) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe... | Bioorg Med Chem Lett 29: 1962-1967 (2019) Article DOI: 10.1016/j.bmcl.2019.05.032 BindingDB Entry DOI: 10.7270/Q2PZ5DBT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
TRAF2 and NCK-interacting protein kinase (Homo sapiens (Human)) | BDBM50535489![]() (CHEMBL4471729) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISA | Bioorg Med Chem Lett 29: 1962-1967 (2019) Article DOI: 10.1016/j.bmcl.2019.05.032 BindingDB Entry DOI: 10.7270/Q2PZ5DBT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
TRAF2 and NCK-interacting protein kinase (Homo sapiens (Human)) | BDBM50535489![]() (CHEMBL4471729) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISA | Bioorg Med Chem Lett 29: 1962-1967 (2019) Article DOI: 10.1016/j.bmcl.2019.05.032 BindingDB Entry DOI: 10.7270/Q2PZ5DBT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |