BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Target of rapamycin complex subunit LST8' and Ligand = 'BDBM50341209'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Target of rapamycin complex subunit LST8 (Homo sapiens)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of N-terminally FLAG-tagged mTORC1 (unknown origin) expressed in HEK293T cells using S6K1 or Akt1 as substrate after 20 mins by immunoblot...				J Med Chem 61: 4656-4687 (2018) Article DOI: 10.1021/acs.jmedchem.7b01019 BindingDB Entry DOI: 10.7270/Q2RR22GW
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Target of rapamycin complex subunit LST8 (Homo sapiens)	BDBM50341209 (9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of mTORC1 in human HCT116 cells assessed as reduction in T389 phosphorylation on RPS6KB1 after 1 hr by Western blot analysis				J Med Chem 61: 4656-4687 (2018) Article DOI: 10.1021/acs.jmedchem.7b01019 BindingDB Entry DOI: 10.7270/Q2RR22GW
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)