Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomeric repeat-binding factor 2-interacting protein 1' and Ligand = 'BDBM50136304' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136304
(CHEMBL3751917)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |r| Show InChI InChI=1S/C72H126N18O18S/c1-14-40(6)56(88-72(108)57(43(9)91)80-46(12)94)69(105)77-37-55(95)81-51(29-33-109-13)64(100)82-49(27-19-22-31-74)65(101)90-59(45(11)93)71(107)87-53(35-39(4)5)67(103)83-48(26-18-21-30-73)63(99)79-41(7)61(97)78-42(8)62(98)86-54(36-47-24-16-15-17-25-47)68(104)84-50(28-20-23-32-75)66(102)89-58(44(10)92)70(106)85-52(60(76)96)34-38(2)3/h15-17,24-25,38-45,48-54,56-59,91-93H,14,18-23,26-37,73-75H2,1-13H3,(H2,76,96)(H,77,105)(H,78,97)(H,79,99)(H,80,94)(H,81,95)(H,82,100)(H,83,103)(H,84,104)(H,85,106)(H,86,98)(H,87,107)(H,88,108)(H,89,102)(H,90,101)/t40-,41-,42-,43+,44+,45+,48-,49-,50-,51-,52-,53-,54-,56-,57-,58-,59-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465 BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this Ligand-Target Pair | |
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136304
(CHEMBL3751917)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |r| Show InChI InChI=1S/C72H126N18O18S/c1-14-40(6)56(88-72(108)57(43(9)91)80-46(12)94)69(105)77-37-55(95)81-51(29-33-109-13)64(100)82-49(27-19-22-31-74)65(101)90-59(45(11)93)71(107)87-53(35-39(4)5)67(103)83-48(26-18-21-30-73)63(99)79-41(7)61(97)78-42(8)62(98)86-54(36-47-24-16-15-17-25-47)68(104)84-50(28-20-23-32-75)66(102)89-58(44(10)92)70(106)85-52(60(76)96)34-38(2)3/h15-17,24-25,38-45,48-54,56-59,91-93H,14,18-23,26-37,73-75H2,1-13H3,(H2,76,96)(H,77,105)(H,78,97)(H,79,99)(H,80,94)(H,81,95)(H,82,100)(H,83,103)(H,84,104)(H,85,106)(H,86,98)(H,87,107)(H,88,108)(H,89,102)(H,90,101)/t40-,41-,42-,43+,44+,45+,48-,49-,50-,51-,52-,53-,54-,56-,57-,58-,59-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465 BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this Ligand-Target Pair | |